New research indicates that individuals who come off popular GLP-1 drugs like Wegovy and Mounjaro may regain reduced body mass far faster than those who stop traditional diet and exercise plans.
Findings released in a leading health publication points out that while overweight individuals often shed a large proportion of their body weight while using the jabs, the weight comes back at an estimated rate of 0.8 kg per month upon discontinuation.
"Users purchasing such drugs must be informed of the danger of fast rebound weight gain when the therapy ends," cautioned lead investigator Dr. Susan Jebb.
Such speed of recovery implies a return to starting mass within about 18 months.
Analyzing Treatments
The study, which examined dozens of trials involving thousands of patients, contrasted the effects of these new drugs with other pills.
Researchers note that individuals who shed pounds through dieting generally see a less rapid weight regain—around 0.1 kg a month—once they finish.
The Reason for the Quick Rebound
Experts believe the way of the drugs explains the accelerated weight return.
These medications copy a natural hormone called GLP-1, which controls hunger.
"Sustained high doses of GLP-1 levels far above than the body's typical production might result in the system to generate a reduced amount of its endogenous hormone, and may also diminish sensitivity to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication means appetite is no longer kept in check, making excessive eating much more probable."
A Lifelong Condition?
Medical guidelines recommend the injections for individuals with weight-linked health risks, alongside recommended diet and exercise modifications.
Professionals contend that, considering the significant potential of relapse, the therapy might need to be life-long.
This perspective is echoed by pharmaceutical companies, who say that the findings "underscore the persistent character of excess weight," comparing it to managing diseases like high blood pressure.
User Accounts
People who have come off the medication explain a powerful resurgence of hunger.
"It was like a trigger flipping and you're instantly ravenous," said one woman.
The struggle is compounded if individuals have not adopted lasting dietary or behavioural changes during treatment.
Widespread Adoption
Survey data suggest that millions of adults in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Use is higher among females than males.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than the NHS.
In conclusion, clinicians caution that while the jabs are powerful agents for weight loss, they are not a standalone fix and maintained weight loss hinges on combined lifestyle support.
